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SELECTED PUBLICATIONS

Dr. Hobbs NCBI Bibliography

  1. Lefler JE, MarElia-Bennett CB, Thies KA, Hildreth BE 3rd, Sharma SM, Pitarresi JR, Han L, Everett C, Koivisto C, Cuitino MC, Timmers CD, O'Quinn E, Parrish M, Romeo MJ, Linke AJ, Hobbs GA, Leone G, Guttridge DC, Zimmers TA, Lesinski GB, Ostrowski MC. STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer. Life Sci Alliance. 2022 Nov;5(11). doi: 10.26508/lsa.202201460. Print 2022 Nov. PubMed PMID: 35803738; PubMed Central PMCID: PMC9270499.

  2. Huynh MV, Hobbs GA, Schaefer A, Pierobon M, Carey LM, Diehl JN, DeLiberty JM, Thurman RD, Cooke AR, Goodwin CM, Cook JH, Lin L, Waters AM, Rashid NU, Petricoin EF 3rd, Campbell SL, Haigis KM, Simeone DM, Lyssiotis CA, Cox AD, Der CJ. Functional and biological heterogeneity of KRASQ61 mutations. Sci Signal. 2022 Aug 9;15(746):eabn2694. doi: 10.1126/scisignal.abn2694. Epub 2022 Aug 9. PubMed PMID: 35944066.

  3. Huynh MV, Parsonage D, Forshaw TE, Chirasani VR, Hobbs GA, Wu H, Lee J, Furdui CM, Poole LB, Campbell SL. Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition. J Biol Chem. 2022 Jun 24;298(8):102186. doi: 10.1016/j.jbc.2022.102186. [Epub ahead of print] PubMed PMID: 35753348; PubMed Central PMCID: PMC9352912.

  4. Javaid S, Schaefer A, Goodwin CM, Nguyen VV, Massey FL, Pierobon M, Gambrell-Sanders D, Waters AM, Lambert KN, Diehl JN, Hobbs GA, Wood KC, Petricoin EF, Der CJ, Cox AD. Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma. Mol Cancer Ther. 2022 May 4;21(5):762-774. doi: 10.1158/1535-7163.MCT-21-0142. PubMed PMID: 35247914; PubMed Central PMCID: PMC9081222. 

  5. Khan I, Koide A, Zuberi M, Ketavarapu G, Denbaum E, Teng KW, Rhett JM, Spencer-Smith R, Hobbs GA, Camp ER, Koide S, O'Bryan JP. Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants. Cell Rep. 2022 Feb 8;38(6):110322. doi: 10.1016/j.celrep.2022.110322. PubMed PMID: 35139380; PubMed Central PMCID: PMC8936000. 

  6. Burge RA, Hobbs GA. Not all RAS mutations are equal: A detailed review of the functional diversity of RAS hot spot mutations. Adv Cancer Res.2022;153:29-61. doi: 10.1016/bs.acr.2021.07.004. Epub 2021 Aug 23. Review. PubMed PMID: 35101234. 

  7. Hobbs GA, Der CJ. KRASG12R-Independent Macropinocytosis in Pancreatic Cancer. Subcell Biochem. 2022;98:205-221. doi: 10.1007/978-3-030-94004-1_11. Review. PubMed PMID: 35378710. 

  8. Waters AM, Khatib TO, Papke B, Goodwin CM, Hobbs GA, Diehl JN, Yang R, Edwards AC, Walsh KH, Sulahian R, McFarland JM, Kapner KS, Gilbert TSK, Stalnecker CA, Javaid S, Barkovskaya A, Grover KR, Hibshman PS, Blake DR, Schaefer A, Nowak KM, Klomp JE, Hayes TK, Kassner M, Tang N, Tanaseichuk O, Chen K, Zhou Y, Kalkat M, Herring LE, Graves LM, Penn LZ, Yin HH, Aguirre AJ, Hahn WC, Cox AD, Der CJ. Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition. Cell Rep. 2021 Jun 29;35(13):109291. doi: 10.1016/j.celrep.2021.109291. PubMed PMID: 34192548; PubMed Central PMCID: PMC8340308. 

  9. Klionsky DJ, ..., Hobbs GA et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PubMed PMID: 33634751; PubMed Central PMCID: PMC7996087. 

  10. Escobar-Hoyos LF, Penson A, Kannan R, Cho H, Pan CH, Singh RK, Apken LH, Hobbs GA, Luo R, Lecomte N, Babu S, Pan FC, Alonso-Curbelo D, Morris JP 4th, Askan G, Grbovic-Huezo O, Ogrodowski P, Bermeo J, Saglimbeni J, Cruz CD, Ho YJ, Lawrence SA, Melchor JP, Goda GA, Bai K, Pastore A, Hogg SJ, Raghavan S, Bailey P, Chang DK, Biankin A, Shroyer KR, Wolpin BM, Aguirre AJ, Ventura A, Taylor B, Der CJ, Dominguez D, Kümmel D, Oeckinghaus A, Lowe SW, Bradley RK, Abdel-Wahab O, Leach SD. Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer. Cancer Cell. 2020 Aug 10;38(2):198-211.e8. doi: 10.1016/j.ccell.2020.05.010. Epub 2020 Jun 18. PubMed PMID: 32559497; PubMed Central PMCID: PMC8028848. 

  11. Hobbs GA, Der CJ. Binge Drinking: Macropinocytosis Promotes Tumorigenic Growth of RAS-Mutant Cancers. Trends Biochem Sci. 2020 Jun;45(6):459-461. doi: 10.1016/j.tibs.2020.02.009. Epub 2020 Mar 9. PubMed PMID: 32413322.

  12. Hobbs GA, Baker NM, Miermont AM, Thurman RD, Pierobon M, Tran TH, Anderson AO, Waters AM, Diehl JN, Papke B, Hodge RG, Klomp JE, Goodwin CM, DeLiberty JM, Wang J, Ng RWS, Gautam P, Bryant KL, Esposito D, Campbell SL, Petricoin EF 3rd, Simanshu DK, Aguirre AJ, Wolpin BM, Wennerberg K, Rudloff U, Cox AD, Der CJ. Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer. Cancer Discov. 2020 Jan;10(1):104-123. doi: 10.1158/2159-8290.CD-19-1006. Epub 2019 Oct 24. PubMed PMID: 31649109; PubMed Central PMCID: PMC6954322. 

  13. Hobbs GA, Der CJ. RAS Mutations Are Not Created Equal. Cancer Discov. 2019 Jun;9(6):696-698. doi: 10.1158/2159-8290.CD-19-0406. PubMed PMID: 31160330. 

  14. Bryant KL, Stalnecker CA, Zeitouni D, Klomp JE, Peng S, Tikunov AP, Gunda V, Pierobon M, Waters AM, George SD, Tomar G, Papke B, Hobbs GA, Yan L, Hayes TK, Diehl JN, Goode GD, Chaika NV, Wang Y, Zhang GF, Witkiewicz AK, Knudsen ES, Petricoin EF 3rd, Singh PK, Macdonald JM, Tran NL, Lyssiotis CA, Ying H, Kimmelman AC, Cox AD, Der CJ. Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer. Nat Med. 2019 Apr;25(4):628-640. doi: 10.1038/s41591-019-0368-8. Epub 2019 Mar 4. PubMed PMID: 30833752; PubMed Central PMCID: PMC6484853. 

  15. Gangi Setty T, Mowers JC, Hobbs AG, Maiya SP, Syed S, Munson RS Jr, Apicella MA, Subramanian R. Molecular characterization of the interaction of sialic acid with the periplasmic binding protein from Haemophilus ducreyi. J Biol Chem. 2018 Dec 28;293(52):20073-20084. doi: 10.1074/jbc.RA118.005151. Epub 2018 Oct 12. PubMed PMID: 30315109; PubMed Central PMCID: PMC6311513. 

  16. Waters AM, Ozkan-Dagliyan I, Vaseva AV, Fer N, Strathern LA, Hobbs GA, Tessier-Cloutier B, Gillette WK, Bagni R, Whiteley GR, Hartley JL, McCormick F, Cox AD, Houghton PJ, Huntsman DG, Philips MR, Der CJ. Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies. Sci Signal. 2017 Sep 26;10(498). doi: 10.1126/scisignal.aao3332. PubMed PMID: 28951536; PubMed Central PMCID: PMC5812265. 

  17. Hobbs GA, Der CJ, Rossman KL. RAS isoforms and mutations in cancer at a glance. J Cell Sci. 2016 Apr 1;129(7):1287-92. doi: 10.1242/jcs.182873. Epub 2016 Mar 16. Review. PubMed PMID: 26985062; PubMed Central PMCID: PMC4869631. 

  18. Hobbs GA, Wittinghofer A, Der CJ. Selective Targeting of the KRAS G12C Mutant: Kicking KRAS When It's Down. Cancer Cell. 2016 Mar 14;29(3):251-253. doi: 10.1016/j.ccell.2016.02.015. Review. PubMed PMID: 26977877. 

  19. Hobbs GA, Mitchell LE, Arrington ME, Gunawardena HP, DeCristo MJ, Loeser RF, Chen X, Cox AD, Campbell SL. Redox regulation of Rac1 by thiol oxidation.Free Radic Biol Med. 2015 Feb;79:237-50. doi: 10.1016/j.freeradbiomed.2014.09.027. Epub 2014 Oct 5. PubMed PMID: 25289457; PubMed Central PMCID: PMC4708892. 

  20. Brady DC, Crowe MS, Turski ML, Hobbs GA, Yao X, Chaikuad A, Knapp S, Xiao K, Campbell SL, Thiele DJ, Counter CM. Copper is required for oncogenic BRAF signalling and tumorigenesis. Nature. 2014 May 22;509(7501):492-6. doi: 10.1038/nature13180. Epub 2014 Apr 9. PubMed PMID: 24717435; PubMed Central PMCID: PMC4138975. 

  21. Hobbs GA, Zhou B, Cox AD, Campbell SL. Rho GTPases, oxidation, and cell redox control. Small GTPases. 2014;5:e28579. doi: 10.4161/sgtp.28579. Epub 2014 May 8. Review. PubMed PMID: 24809833; PubMed Central PMCID: PMC4114927. 

  22. Hobbs GA, Gunawardena HP, Campbell SL. Biophysical and proteomic characterization strategies for cysteine modifications in Ras GTPases. Methods Mol Biol. 2014;1120:75-96. doi: 10.1007/978-1-62703-791-4_6. PubMed PMID: 24470020; PubMed Central PMCID: PMC4067004. 

  23. Hobbs GA, Gunawardena HP, Baker R, Campbell SL. Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.Small GTPases. 2013 Jul-Sep;4(3):186-92. doi: 10.4161/sgtp.26270. Epub 2013 Sep 12. PubMed PMID: 24030601; PubMed Central PMCID: PMC3976977. 

  24. Hobbs GA, Bonini MG, Gunawardena HP, Chen X, Campbell SL. Glutathiolated Ras: characterization and implications for Ras activation. Free Radic Biol Med. 2013 Apr;57:221-9. doi: 10.1016/j.freeradbiomed.2012.10.531. Epub 2012 Oct 30. PubMed PMID: 23123410; PubMed Central PMCID: PMC3985386. 

  25. Mitchell L, Hobbs GA, Aghajanian A, Campbell SL. Redox regulation of Ras and Rho GTPases: mechanism and function. Antioxid Redox Signal. 2013 Jan 20;18(3):250-8. doi: 10.1089/ars.2012.4687. Epub 2012 Jul 30. Review. PubMed PMID: 22657737; PubMed Central PMCID: PMC3518547. 

  26. Bhaskar K, Hobbs GA, Yen SH, Lee G. Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy.Neuropathol Appl Neurobiol. 2010 Oct;36(6):462-77. doi: 10.1111/j.1365-2990.2010.01103.x. PubMed PMID: 20609109; PubMed Central PMCID: PMC2939304.

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